Staphylococcal Protein A as a Pharmacological Treatment for Autoimmune Disorders
نویسندگان
چکیده
Staphylococcal protein A (SpA) is a key virulence factor that enables Staphylococcus aureus to evade host innate and adaptive immune responses. The immunomodulatory properties of SpA have led to a hypothesis that it may have pharmacological applications as a treatment for autoimmune disease. Clinical trials are underway to test whether ultrapure SpA can be used to treat immune thrombocytopenia and rheumatoid arthritis. Here, we examine the potential of SpA as an innovative drug to manage autoimmune movement disorders.
منابع مشابه
Skin-induced tolerance as a new needle free therapeutic strategy.
This article summarizes current knowledge about a new subject called "skin induced tolerance". Suppression is induced via epicutaneous (EC) immunization with a protein antigen and is described in Th1, Tc1 and NK mediated contact hypersensitivity (CHS) reactions. The subject of skin-induced suppression is also described in the regulation of experimental models of autoimmune diseases like experim...
متن کاملEpicutaneous immunization with myelin basic protein protects from the experimental autoimmune encephalomyelitis.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) with limited treatment modalities. One of the experimental methods that protect from autoimmune diseases is oral tolerance. However, this method failed to show therapeutic efficacy in clinical trials. In our previous work, we found that epicutaneous (ec) immunization with a protein antigen i...
متن کاملP 53: Stem Cell Therapy for Treatment of Autoimmune Diseases (with Emphasis on Multiple Sclerosis)
Autoimmune diseases have been described as an interesting and poorly understood group of disorders. There are many challenges in the respective scientific societies concerning the nature, causes and the therapeutic approaches of these diseases. In accordance with the evidences the nature and etiology of these disorders is multifactorial and complex but the clearest definition could be expressed...
متن کاملO 8: Tenasin-C as a New Target for Multiple Sclerosis Treatment
Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...
متن کاملMetabotropic glutamate receptors and their ligands applications in neurological and psychiatric disorders
Metabotropic glutamate receptors (mGluRs) consist of a large family of G-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. The wide distribution and diverse physiological roles of various mGluR subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. The discovery of ...
متن کامل